For family offices, funds and angels

Investors

Deal flow in physical industry, sourced from real meetings rather than scraped lists — and allocated deal by deal, with no fund commitment.

See the calendar
Where this already works

Boston, at The Engine.

September 17 at MIT's tough-tech campus — accredited investors, founders building in the physical world, and the people who fund them.

Boston · September 17

The Engine at MIT

Exclusively for accredited investors. Companies presented to the room, introductions were made by name, and the conversations carried on well past the programme.

Sponsored by
4IR GroupFinStrat ManagementThe EngineNixon PeabodyFidelity
See the event page
Why rooms

The round after ours is decided in rooms, not inboxes.

Introductions made by name, in front of the people who actually allocate.

How allocation works

Deal by deal, not blind pool.

You are not committing to a fund and waiting to find out what it bought. Every opportunity comes to you on its own, in its own vehicle, and you decide on that one.

  1. 01

    We source and select

    Companies building in the physical world, assessed against a published bar. Most do not make it through.

  2. 02

    We form an SPV

    A vehicle per company, per round. You see the company, the terms and the allocation before anything is committed.

  3. 03

    You allocate

    Take the ones that fit your thesis and pass on the rest. Co-invest alongside the other investors in the room.

In the portfolio

What we have backed.

The kind of company that comes through the process above, and what we looked for when it did.

Seco Bio

Probiotics die before they arrive. Seco Bio keeps them alive from the factory to the moment they are used.

seco.bio
Sector
Biotechnology — shelf-stable live cultures
Why we backed it
A physical problem with a physical fix, not a formulation claim
Evidence
Proprietary formulation, validated through to the point of use
Presented at
Boston, at The Engine — September 17

Portfolio company information is provided for background only. Nothing on this page is an offer to sell or a solicitation of an offer to buy any security, and it is not investment, legal or tax advice. 4IR Group does not offer securities through this website.

PhAST

When sepsis sets in, doctors guess at antibiotics for days while the lab catches up. PhAST names the one that works in hours.

phast.ai
Sector
Diagnostics — antimicrobial susceptibility testing
Why we backed it
A timing problem measured in lives, with a cleared product against it
Evidence
FDA-cleared panel; the fastest susceptibility test on the market
Presented at
Boston, at The Engine — September 17

Portfolio company information is provided for background only. Nothing on this page is an offer to sell or a solicitation of an offer to buy any security, and it is not investment, legal or tax advice. 4IR Group does not offer securities through this website.

Syntis Bio

Oral therapies that act through the small intestine’s own biology — a pill where the working obesity drugs are injections.

syntis.bio
Sector
Biotechnology — oral therapeutics
Why we backed it
A delivery route that changes who can be treated, not just how well
Evidence
Pipeline across multiple therapeutic areas, led by obesity
Presented at
Boston, at The Engine — September 17

Portfolio company information is provided for background only. Nothing on this page is an offer to sell or a solicitation of an offer to buy any security, and it is not investment, legal or tax advice. 4IR Group does not offer securities through this website.

Calendar

Where we are this fall ’26, and who we are presenting.

Six private evenings, each with portfolio companies presenting to the room. Invitation-only, and registration is subject to host approval.

  • Oct
    8
    Investor evening

    Boston, MA

    Thursday · 6:00 – 9:00 PM — companies present uninterrupted, introductions made by name, and the hour afterwards that does the actual work.

    Register
  • Oct
    13
    Investor evening

    Salt Lake City, UT

    Tuesday · 6:00 – 9:00 PM MDT — companies present uninterrupted, introductions made by name, and the hour afterwards that does the actual work.

    Register
  • Oct
    27
    Investor evening

    Beverly Hills, CA

    Tuesday · 6:00 – 9:00 PM PDT — companies present uninterrupted, introductions made by name, and the hour afterwards that does the actual work.

    Register
  • Nov
    3
    Investor evening

    Palo Alto, CA

    Tuesday · 6:00 – 8:00 PM PST — companies present uninterrupted, introductions made by name, and the hour afterwards that does the actual work.

    Register
  • Nov
    5
    Investor evening

    Palm Beach, FL

    Thursday · 6:00 – 9:00 PM — companies present uninterrupted, introductions made by name, and the hour afterwards that does the actual work.

    Register
  • Nov
    12
    Investor evening

    Chicago, IL

    Thursday · 6:00 – 9:00 PM — companies present uninterrupted, introductions made by name, and the hour afterwards that does the actual work.

    Register
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Tell us your thesis.

What you deploy into, at what size, and at what stage. We only come to you when something actually fits it.